Apparently, the universe will reach heat death in the extremely far future, after the last black holes would have evaporated. Even more, it is possible that all objects in the universe will turn into black holed via quantum tunneling 1 2 3, so at the end nothing will remain in the universe except for residual thermal radiation in thermodynamic equilibrium
But, even if objects in extremely long timescales would quantum tunnel into black holes by quantum fluctuations, could there be also some quantum fluctuations that would make new particles to form (using the energy "leftovers" of the universe after heat death)? Or because energy (like electromagnetic radiation) will be redshifted, there will be a point where this would be impossible?